Adiposome Proteomics Uncover Molecular Signatures of Cardiometabolic Risk in Obese Individuals.

ABSTRACT:

Background

Adipose-derived extracellular vesicles (adiposomes) are emerging as key mediators of inter-organ communication, yet their molecular composition and role in obesity-related pathophysiology remain underexplored. This study integrates clinical phenotyping with proteomic analysis of visceral adipose-derived adiposomes to identify obesity-linked molecular disruptions.

Methods

Seventy-five obese and forty-seven lean adults were extensively profiled for metabolic, inflammatory, hepatic, and vascular parameters. Adiposomes isolated from visceral fat underwent mass spectrometry-based proteomic analysis, followed by differential abundance, pathway enrichment, regulatory network modeling, and clinical association testing.

Results

Obese individuals exhibited widespread

SUBMITTER: Rakab MS 

PROVIDER: S-EPMC12452415 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature