Validation of the novel Eosinophilic Esophagitis Symptom Questionnaire.

ABSTRACT:

Objective

The novel Eosinophilic Esophagitis Symptom Questionnaire (EoE-SQ) is a patient-reported outcome measure that assesses symptoms beyond dysphagia in adults and adolescents with eosinophilic esophagitis (EoE).

Methods

The EoE-SQ was administered in the phase 3 R668-EE-1774 trial (NCT03633617), which assessed the efficacy and safety of dupilumab in adults and adolescents with EoE. Baseline and follow-up data were used to estimate its psychometric properties and to determine meaningful score change.

Results

The sample included 239 patients (median [range] age, 24 [12-68] years). The EoE-SQ frequency/severity scores showed internal consistency and test-retest reliability. Construct validity was demonstrated through moderate-to-strong correlations between EoE-SQ fr

SUBMITTER: McCann E 

PROVIDER: S-EPMC12452589 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature