Diagnostic Accuracy of Neutrophil Gelatinase-Associated Lipocalin in Peritoneal Effluent and Ascitic Fluid for Early Detection of Peritonitis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Peritonitis in peritoneal dialysis and cirrhosis remains common and leads to morbidity. Neutrophil gelatinase-associated lipocalin (NGAL) has been evaluated as a rapid adjunctive biomarker.

Methods

Following PRISMA-DTA and PROSPERO registration (CRD420251105563), we searched MEDLINE, Embase, Cochrane Library, LILACS, Scopus, and Web of Science from inception to 31 December 2024, and ran an update on 30 June 2025 (no additional eligible studies). Diagnostic accuracy studies measuring NGAL in peritoneal/ascitic fluid against guideline reference standards were included. When 2 × 2 data were not reported, we reconstructed cell counts from published metrics using a prespecified, tolerance-bounded algorithm (two studies). Accuracy was synthesized with a bivariate random

SUBMITTER: Prieto-Magallanes ML 

PROVIDER: S-EPMC12452612 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature