Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuR.

ABSTRACT: RNA-binding proteins (RBPs) play essential roles in all major steps of RNA processing. Genetic studies in human and mouse models support that many RBPs are crucial for maintaining homeostasis in key tissues/organs, but to what extent the function of RBPs is conserved between humans and mice is not clear. Our recent study using a chimeric humanized liver mouse model found that knocking down human HuR in human hepatocytes resulted in a broad upregulation of human genes involved in fatty acid catabolism. This regulation is human-specific, as the knocking down of mouse HuR in the liver of traditional mouse models did not show these effects. To further study this human-specific role of HuR, we co-overexpressed HuR with PPARα, a master transcription factor that promotes fatty acid catabolism, in

SUBMITTER: Takaoka S 

PROVIDER: S-EPMC12452626 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature