Combined Naltrexone-Bupropion Therapy for Concurrent Cocaine Use Disorder and Obesity: A Case Report.

ABSTRACT: Background and Clinical Significance: Cocaine use disorder (CUD) is characterized by recurrent, cue-triggered and intrusive urges to use cocaine (craving), compulsive drug-seeking despite adverse consequences, and impaired control over intake, often co-occurring with excess weight and hedonic overeating. A dual-target rationale supports the fixed-dose naltrexone-bupropion (NB) combination: μ-opioid receptor (MOR) antagonism may mitigate opioid-facilitated mesolimbic reinforcement, while bupropion's catecholaminergic effects and POMC activation support satiety and weight loss. Case Presentation: We describe a case study from an Italian outpatient setting of a 35-year-old man with a 10-year history of CUD, multiple failed detoxifications, and class I obesity (body mass index [B

SUBMITTER: Romeo VM 

PROVIDER: S-EPMC12452683 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature