Effects of Haloperidol on Cardiac Histamine H₂ Receptors and β-Adrenoceptors in Isolated Mouse and Human Atrial Preparations.

ABSTRACT: The antipsychotic drug haloperidol is found on the WHO list of essential drugs. In vitro, haloperidol demonstrates binding affinity for various receptors, including histamine H₂ receptors (H₂Rs). Several cardiac effects of haloperidol are known, but it remains unclear whether H₂Rs are involved. Here, the hypothesis was tested that haloperidol has the potential to act as either an agonist or an antagonist of human cardiac H₂Rs. The contractile effects of haloperidol were studied in isolated left and right atrial preparations from transgenic mice overexpressing human H₂Rs in the heart (H₂-TG), and compared to human atrial preparations from adult patients. Haloperidol reduced the histamine-stimulated force of contraction in the

SUBMITTER: Schlicht JMA 

PROVIDER: S-EPMC12452768 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature