Trends in depression related cardiovascular mortality among adults from 1999 to 2020: a retrospective study in the United States.

ABSTRACT:

Background

Cardiovascular disease (CVD) and depression frequently coexist, leading to worse outcomes and higher mortality than CVD alone. Despite this impact, long-term trends in cardiovascular mortality among adults with depression remain underexplored.

Methods

We used the CDC WONDER database to obtain death certificate data from 1999 to 2020 for adults aged ≥25 years. Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 population were extracted. Annual percent change (APC) and average APC (AAPC) were estimated using Joinpoint regression and compared to the general population using pairwise comparison.

Results

A total of 79,813 CVD deaths occurred in adults with depression. Mortality trends were stable until 2002 (APC: 0.14), declined si

SUBMITTER: Ahmed S 

PROVIDER: S-EPMC12452842 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature