Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors.

ABSTRACT: Multivalent binding and the resulting dynamical clustering of receptors and ligands are known to be key features in biological interactions. For optimizing biomaterials capable of similar dynamical features, it is essential to understand the first step of these interactions, namely the multivalent molecular recognition between ligands and cell receptors. Here, we present the reciprocal cooperation between dynamic ligands in supramolecular polymers and dynamic receptors in model cell membranes, determining molecular recognition and multivalent binding via receptor clustering. The nonlinear dependences of the ligand concentration, receptors, and their binding affinity are observed experimentally by fluorescence and superresolution fluorescence microscopies, revealing a valency-dependent clus

SUBMITTER: Dhiman S 

PROVIDER: S-EPMC12452917 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature