Microglia-to-neuron signaling links <i>APOE4</i> and inflammation to enhanced neuronal lipid metabolism and network activity.

ABSTRACT: Microglia regulate neuronal circuit plasticity. Disrupting their homeostatic function has detrimental effects on neuronal circuit health. Neuroinflammation contributes to the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), with several microglial activation genes linked to increased risk for these conditions. Inflammatory microglia alter neuronal excitability, inducing metabolic strain. Interestingly, expression of APOE4, the strongest genetic risk factor for AD, affects both microglial activation and neuronal excitability, highlighting the interplay between lipid metabolism, inflammation, and neuronal function. It remains unclear how microglial inflammatory state is conveyed to neurons to affect circuit function and whether APOE4 expr

SUBMITTER: Verduzco Espinoza AP 

PROVIDER: S-EPMC12452947 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature