CAPG Regulates Doxorubicin Resistance in Hepatocellular Carcinoma Cells via TGFB1/Smad/Nrf2 Signalling Pathway.

ABSTRACT: Hepatocellular carcinoma (HCC) is a common and deadly type of liver cancer with limited treatment options and a considerable issue with chemoresistance. This study investigates the role of the cytoskeleton-associated protein G (CAPG) gene in HCC and explores its expression, clinical relevance, as well as the molecular mechanisms on doxorubicin (Dox) resistance. Employing bioinformatics, immunohistochemistry, cell-based assays and animal models, we systematically explored CAPG's function in HCC. Our results demonstrated that CAPG was markedly upregulated in HCC tissues and cell lines compared to normal controls (***p < 0.001). High CAPG expression was associated with poor overall survival (HR = 1.98, p < 0.001) and unfavourable clinicopathological parameters, indicating its potential as a p

SUBMITTER: Shang Y 

PROVIDER: S-EPMC12453004 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature