Effects of influenza A infection on liberation of bacteria from biofilms and inflammatory response in an <i>in vitro</i> model of chronic rhinosinusitis.

ABSTRACT: Chronic rhinosinusitis (CRS) is a prevalent and life-altering disease characterized by the persistent inflammation of the sinuses lasting longer than 3 months. Pseudomonas aeruginosa (PA) is a prominent biofilm-forming bacterium that colonizes the sinuses of up to 9% of CRS patients. PA in biofilm exhibits a great resistance to antibiotics and has proven difficult to remove from the sinus mucosa of CRS patients. Influenza A virus (IAV) is the second most common virus detected colonizing CRS patients' sinuses, with previous studies finding that IAV-induced inflammation of human cells causes the dispersal of bacteria encased in biofilms, leading to increased disease exacerbations. Yet, the two pathogens and the effect that co-infection with them has on primary human nasal epithelial c

SUBMITTER: Hall J 

PROVIDER: S-EPMC12453117 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature