The combined effects of tick defensin persulcatusin with conventional antibiotics and antimicrobial proteins/peptides against <i>Staphylococcus aureus</i>.

ABSTRACT: Persulcatusin (IP) is a tick defensin isolated from Ixodes persulcatus and is composed of 38 aa (molecular weight of 4,200). IP exhibits potent antimicrobial activity against Staphylococcus aureus, including drug-resistant strains, such as methicillin- and vancomycin-resistant S. aureus. Despite its potential use as an anti-S. aureus drug, its application remains underdeveloped because of several limitations, such as manufacturing costs and in vivo safety. Here, the combined effect of IP and other conventional antibiotics and antimicrobial proteins/peptides against S. aureus bacterial infections was investigated. Combinations of several antimicrobial compounds, including β-lactams, peptide antibiotics and lytic enzymes, showed a synergistic

SUBMITTER: Shimoda S 

PROVIDER: S-EPMC12453121 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature