Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids.

ABSTRACT:

Background

Bronchopulmonary dysplasia (BPD), a common morbidity among very preterm infants, is associated with chronic disease and neurodevelopmental impairments. A hypothesized mechanism for these outcomes lies in altered glucocorticoid (GC) activity. We hypothesized that BPD and its treatments may result in epigenetic differences in the hypothalamic-pituitary-adrenal (HPA) axis, which is modulated by GC, and could be ascertained using an established GC risk score and DNA methylation (DNAm) of HPA axis genes.

Methods

DNAm was quantified from buccal tissue (ECHO-NOVI) and from neonatal blood spots (ELGAN ECHO) via the EPIC microarray. Prenatal maternal characteristics, pregnancy complication, and neonatal medical complication data were collected from medical record review an

SUBMITTER: Hodge KM 

PROVIDER: S-EPMC12453144 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature