Active electroceutical treatment of Pseudomonas aeruginosa infected murine wounds.

ABSTRACT: Chronic, infected dermal wounds have a high burden of cost and remain a persistent hurdle within healthcare. Electroceutical dressings that deliver antimicrobial agents directly to the wound site have emerged as an alternative solution to current standards of care. Here, through a systematic evaluation in an infected murine wound model we report on an actively powered electroceutical dressing that generates hypochlorous acid in situ as an antimicrobial agent to clear infection. In a significant new discovery, we also report that the treatment of these infected wounds with the actively powered electroceutical promotes the closure of wounds better than other test conditions. In a 10-day murine study, mice were wounded, and the dermal injury was infected with Pseudomonas aeruginosa. Four trea

SUBMITTER: Mack CR 

PROVIDER: S-EPMC12453229 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature