The diversity of clinical <i>Mycobacterium abscessus</i> isolates in morphology, glycopeptidolipids and infection rates in a macrophage model.

ABSTRACT: Introduction. Mycobacterium abscessus (MABS) is a pathogenic bacterium that can cause severe lung infections, particularly in individuals with cystic fibrosis. MABS colonies can exhibit either a smooth (S) or rough (R) morphotype, influenced by the presence or absence of glycopeptidolipids (GPLs) on their surface, respectively. Despite the clinical significance of these morphotypes, the relationship between GPL levels, morphotype and the pathogenesis of MABS infections remains poorly understood.Gap statement. The mechanisms and implications of GPL production and morphotypes in clinical MABS infections are unclear. There is a gap in understanding their correlation with infectivity and pathogenicity, particularly in patients with underlying lung disease.Aim. This

SUBMITTER: Pichler V 

PROVIDER: S-EPMC12453391 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature