Genomic surveillance of invasive <i>Streptococcus pneumoniae</i> strains in south Tunisia during 2012-2022.

ABSTRACT: Purpose. Invasive pneumococcal disease (IPD) remains a major global public health concern due to its high morbidity and mortality rates, particularly among children and the elderly. This study aimed to apply whole-genome sequencing (WGS) to characterize Streptococcus pneumoniae strains responsible for IPD in south Tunisia, including serotype distribution, clonal relationship and antimicrobial resistance (AMR) profiles.Methods. A total of 148 IPD S. pneumoniae isolates were collected from the microbiology laboratory at Habib Bourguiba University Hospital in Sfax, Tunisia, between 2012 and 2022. These isolates underwent WGS using Illumina technology. Bioinformatic analyses were performed to determine serotype distribution, sequence types (STs), Global Pneumococcal

SUBMITTER: Smaoui F 

PROVIDER: S-EPMC12453412 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature