Maternal Smoking During Pregnancy Interacts With Genetic Factors to Increase Risk for Low Birth Weight but Not Harmful Offspring Smoking Behaviors in Europeans.

ABSTRACT:

Introduction

Pregnant individuals who smoke face increased health risks because smoking harms both the mother and their developing offspring.

Aims and methods

Using 307 417 Europeans from the UK Biobank, we examined whether exposure to maternal smoking during pregnancy (MSP) interacts with genetic risk to predict offspring birth weight (BW) and smoking behaviors. We investigated interactions between MSP and genetic risk at multiple levels: single variant, gene level, and polygenic score. We examined self-reported BW, smoking initiation status (SI), age of smoking initiation, cigarettes per day, and smoking cessation status.

Results

One locus tagged by single-nucleotide polymorphism rs72689499 on chromosome 14 reached significance for interaction with MSP on the multip

SUBMITTER: Romero Villela PN 

PROVIDER: S-EPMC12453677 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature