Comparison of amyloid PET acquired through standardized and unstandardized protocols.

ABSTRACT:

Introduction

Amyloid positron emission tomography (PET) scans collected by Alzheimer's Disease Research Centers (ADRCs) include site-specific "mixed protocols" and, since 2021, standardized protocols through the Standardized, Centralized AD/ADRD Neuroimaging initiative. We compared amyloid PET from cohorts using unstandardized versus standardized pre-processing protocols.

Methods

Across cohorts, amyloid measured in Centiloids (CLs) was derived from 18F-florbetapir (FBP), 18F-florbetaben (FBB), 11C-Pittsburgh compound B (PIB), and 18F-NAV4694 (NAV) scans using identical magnetic resonance imaging-free post-processing pipelines. We evaluated CL distributions across cohorts and tracers using Gaussian mixture models (GMMs).

Results

Within each tracer, GMM-derived amyloid

SUBMITTER: Cody KA 

PROVIDER: S-EPMC12453954 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature