Causal Effects of Plasma Proteins in Polycystic Ovary Syndrome: A Proteome-Wide Mendelian Randomization Study.

ABSTRACT:

Background and aims

Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder with complex pathogenesis and limited targeted therapeutic options. This study presents a proteomics-informed approach to identify potential plasma protein targets for PCOS intervention using causal inference methods.

Methods

We conducted a comprehensive proteome-wide Mendelian randomization analysis by integrating 1 Mb plasma cis-acting protein quantitative trait loci datasets with PCOS genome-wide association study summary statistics. To enhance robustness, we applied complementary approaches including summary-data-based MR, the Heterogeneity in Dependent Instruments test, and colocalization analysis. Identified targets were further assessed for druggability using curated d

SUBMITTER: Yu T 

PROVIDER: S-EPMC12453959 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature