Idiopathic inflammatory myopathy associated with Sjogren's disease: features of a distinct clinical entity.

ABSTRACT:

Background

Idiopathic inflammatory myopathies (IIM) and Sjögren's disease (SjD) may coexist, but data on their combined presentation and treatment response remain limited.

Methods

We retrospectively analyzed 23 patients with biopsy-confirmed IIM and coexisting SjD, compared to 24 age- and sex-matched IIM controls without SjD. Clinical, electrophysiological, and immunological data, as well as treatments and outcomes, were assessed. Outcome assessment included EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) and the ACR/EULAR Myositis Response Criteria for adult polymyositis and dermatomyositis.

Results

Among IIM-SjD patients, 39% had inclusion body myositis (IBM), 61% had poly- or dermatomyositis. Compared to controls, asymmetric muscle weakness (78%, p=0.0012)

SUBMITTER: Konen FF 

PROVIDER: S-EPMC12454105 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature