Comparison of nasal microbiota between preterm and full-term infants in early life.

ABSTRACT:

Background

The respiratory microbiota influences infant immune system maturation. Little is known about how perinatal, physiological, and environmental exposures impact the nasal microbiota in preterm infants after discharge, or nasal microbiota differences between preterm and healthy full-term infants.

Methods

Nasal swabs (from 136 preterm and 299 full-term infants at mean postmenstrual age of 45 weeks from the prospective Basel-Bern Infant Lung Development cohort) were analyzed by 16S-rRNA gene amplification and sequencing (Illumina MiSeq). Associations were tested with multivariable linear regression and principal coordinate analysis.

Results

Presence of older siblings in preterm infants was associated with β-diversity (PERMANOVA p = 0.001) and an increased abundan

SUBMITTER: Gorlanova O 

PROVIDER: S-EPMC12454110 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature