Impact of early nutrition on brain development and neurocognitive outcomes in very preterm infants.

ABSTRACT:

Background

Malnutrition of preterm infants may negatively affect brain growth and later neurocognitive function. We aimed to investigate the association between very preterm infants' macronutrient intakes, and brain MRI at term and neurodevelopment at 2 years.

Methods

Single-center, retrospective cohort including extremely (22-27w) and very (28-31w) preterm infants born 2011-2014. The intakes of fluid, protein, carbohydrate, fat, and total calories during days 0-28 together with body weights were assessed in relation to brain MRI (morphology, volumetry, diffusion-weighted imaging) at term, and cognition (BSID-III) at 2 years, using adjusted multivariable regression analyses.

Results

Seventy-two infants were included. A lower (p < 0.001) caloric intake in extremely pre

SUBMITTER: Naseh N 

PROVIDER: S-EPMC12454131 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature