Positive impact of sodium L-lactate supplementation on blood acid-base status in preterm newborns.

ABSTRACT:

Background

Preclinical studies indicate that lactate is a crucial cerebral energy substrate, with Na-L-lactate administration significantly reducing brain lesion volumes and improving motor and cognitive functions following neonatal hypoxia-ischemia in rat pups. Its neuroprotective effects are linked to neuronal metabolic utilization, making it a promising candidate for treating newborns with hypoxia-ischemia encephalopathy, a condition where hypothermia remains the only established therapy. However, before initiating a clinical trial, it is necessary to assess the effects of Na-L-lactate infusion on blood parameters.

Methods

We retrospectively analyzed blood parameters in 60 premature neonates during their first days of life. Among them, 30 received Na-L-lactate instead of

SUBMITTER: Omar Ibrahim I 

PROVIDER: S-EPMC12454137 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature