Association of TRDMT1 Gene Polymorphisms With Neuroblastoma Susceptibility: Insights From a Case-Control Study.

ABSTRACT: Neuroblastoma is the most common extracranial solid tumour in children, and genetic susceptibility plays a crucial role in its development. The impact of tRNA Dimethyltransferase 1 (TRDMT1), a primary methyltransferase catalysing 5-methylcytosine (m5C) RNA modification, on neuroblastoma susceptibility remains unexplored. We conducted a case-control study involving 402 neuroblastoma patients and 473 controls from Jiangsu, China. TRDMT1 polymorphisms (rs7074891 T>C, rs10904887 T>C and rs2273734 C>T) were genotyped via the TaqMan assay. Logistic regression was used to assess odds ratios (ORs) and 95% confidence intervals (CIs), while stratification analysis and expression quantitative trait locus (eQTL) analysis were used to examine subgroup-specific effects and regulatory impacts. Additional

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12454185 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature