Early Long-Chain Polyunsaturated Fatty Acids Supplementation on Long- and Short-Term Neurodevelopmental Outcomes in Preterm or Low Birth Weight Infants: A Meta-Analysis.

ABSTRACT: Long-chain polyunsaturated fatty acid (LCPUFA) supplementation on neurodevelopmental outcomes in preterm or low birth weight (LBW) infants is controversial. This study aims to evaluate the effects of early LCPUFA supplementation on short- and long-term neurodevelopmental outcomes in preterm or LBW infants. This study was previously registered (CRD42024503566). We searched MEDLINE, Embase, PsycInfo, ClinicalTrials.gov and Cochrane Database through January 2024. Randomised clinical trials (RCTs) or follow-up studies comparing early LCPUFA supplementation to placebo or no supplementation in preterm or LBW infants were included. Outcomes assessed included long-term (≥ 5 years) and short-term (< 5 years) measures, such as IQ, neurodevelopmental impairment (NDI), mental development index (MDI) a

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12454187 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature