Mechanisms of Baishao () and Gancao () on major depressive disorder: network pharmacology and o validation.

ABSTRACT:

Objective

To elucidate the potential molecular mechanisms of Baishao (Radix Paeoniae Alba) (APR) and Gancao (Radix Glycyrrhizae) (GR) in the treatment of major depressive disorder (MDD).

Methods

Based on the network pharmacology strategy, the therapeutic targets of APR-GR for MDD are predicted, differentially expressed genes from the Integrated Gene Expression database for MDD patients. Topological networks are constructed, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways are enriched, their pharmacological potential molecular mechanisms are discussed, and molecular docking analysis is performed to further motivate compositional and target interactions. Finally, the CUMS mouse model is used for validation.

Results

Based on the pharmacol

SUBMITTER: Ke P 

PROVIDER: S-EPMC12454256 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature