Jianpi Yifei Tongluo recipe attenuates inflammation by promoting the expression of interferon regulatory factor 4 in the rat model of chronic obstructive pulmonary disease.

ABSTRACT:

Objective

To examine the effects of the Jianpi Yifei Tongluo recipe (, JYTR) on chronic obstructive pulmonary disease (COPD) within an animal model and to elucidate its anti-inflammatory mechanisms.

Methods

In this study, we utilized cigarette smoke (CS) exposure and lipopolysaccharide (LPS)-induced models of COPD in rats to evaluate the effects of the JYTR on airway inflammation. Sprague-Dawley rats were randomly assigned to various groups: control, model, budesonide, synbiotics, and low, medium, and high JYTR. Pulmonary function was gauged using an animal volumetric tracer. Pathological alterations in lung tissue were examined under a light microscope. To ascertain cytokine production, we conducted enzyme-linked immunosorbent assay tests, and we employed Western blotting t

SUBMITTER: Wei W 

PROVIDER: S-EPMC12454260 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature