Comparative analysis of target volume coverage and liver exposure in high-dose-rate interstitial brachytherapy and <i>in silico</i> MR LINAC-based stereotactic body radiotherapy plans for colorectal liver metastases.

ABSTRACT:

Background

This study compared the plan quality and dosimetric parameters of single-fraction (SF) MR-LINAC (MRL)-based stereotactic body radiotherapy (SBRT) with delivered high-dose-rate interstitial brachytherapy (HDR-iBT) for colorectal liver metastases (CRLM).

Methods

Between August 2017 and March 2019, 26 patients with a total of 45 CRLM were treated in 28 sessions using HDR-iBT with 1 × 25 Gy and were retrospectively included in this study. For each patient, an in silico MRL-based SBRT plan was generated using the corresponding iBT CT dataset. In the iBT plans, a single fraction of 25 Gy was prescribed to the periphery of the gross tumor volumes (GTVs), while in the SBRT plans, the same dose was prescribed to the 80% isodose line covering the planning target volu

SUBMITTER: Mansoorian S 

PROVIDER: S-EPMC12454280 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature