Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives.

ABSTRACT: Bone defect treatment remains a significant clinical challenge, further exacerbated by the demographic transition toward an aging society. In elderly populations, the increased proportion of senescent cells emerges as a fundamental determinant that substantially compromises regenerative outcomes. In senescent bone tissues, the progressive accumulation of senescent cells compromises bone regenerative capacity through multifaceted mechanisms, encompassing both intrinsic functional impairment of senescent cells and the far-reaching impact of the senescence-associated secretory phenotype (SASP) on the surrounding cellular and tissue microenvironment. Advanced biomaterials provide a platform for targeted anti-senescence interventions. One strategy is the selective elimination of senescent cells

SUBMITTER: Wu H 

PROVIDER: S-EPMC12454288 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature