ULK1 gene polymorphisms and severe tuberculosis in the Chinese Han population: a case-control study.

ABSTRACT:

Objectives

Polymorphisms in the uncoordinated 51-like kinase 1 (ULK1) gene are associated with susceptibility to multiple diseases, including neurodegenerative disorders and specific cancer types. In tuberculosis (TB) research, autophagy is recognized as an essential host mechanism against Mycobacterium tuberculosis (Mtb) infection. Consequently, functional variations in the ULK1 gene may affect autophagic efficiency, influencing the host immune response to Mtb and altering the severity of TB. This study aimed to investigate the association between ULK1 gene polymorphisms and severe TB within a Chinese Han population using a case-control study design.

Methods

A case-control study was conducted, with patients diagnosed with mild TB as controls and those diagnosed with

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12454327 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature