Epigenetic modifications in developmental coordination disorder: association between DNA methylation and motor performance.

ABSTRACT:

Objective

Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination. However, the biological mechanisms underlying DCD remain largely unclear. This study aimed to investigate the potential role of DNA methylation in the pathogenesis of DCD.

Methods

Genome-wide DNA methylation analysis was conducted using peripheral blood samples from children with and without DCD. Forty-two key differentially methylated probes (DMPs) were selected for targeted validation using MethylTarget™ sequencing.

Results

A total of 416 DMPs were detected. Using the Bumphunter and ProbeLasso algorithms, 48 and 22 differentially methylated regions (DMRs) were identified, respectively. Among the key DMPs, methylation levels at cg

SUBMITTER: Huang F 

PROVIDER: S-EPMC12454365 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature