Comparative efficacy and safety of antidiabetic agents for post-transplant diabetes mellitus: a network meta-analysis.

ABSTRACT:

Background

Post-transplant diabetes mellitus (PTDM) significantly compromises patient and graft outcomes. Although multiple antidiabetic agents are available, their comparative efficacy and safety profiles in this population remain uncertain.

Methods

A systematic literature search was performed across PubMed, Web of Science, Embase, and Cochrane Library to identify clinical trials comparing antidiabetic therapies in PTDM patients. Risk of bias was assessed, and a network meta-analysis was conducted to estimate relative treatment effects. Treatment ranking probabilities, contribution plots, and funnel plots were used to evaluate hierarchy, study influence, and publication bias, respectively.

Results

Twelve studies-including 10 randomized controlled trials (RCTs) and 2

SUBMITTER: Hu S 

PROVIDER: S-EPMC12454430 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature