The impact of sarcopenia on sarcoma patients: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Sarcopenia has been linked to poor outcomes in various cancers, but its specific effect on sarcoma patients remains unclear. This systematic review and meta-analysis investigates the impact of sarcopenia, estimated using CT, on sarcoma patients, focusing on prognostic implications and associated outcomes.

Materials and methods

The PubMed, Embase, and SCOPUS databases were searched up to March 2025. Then, a meta-analysis of the data was performed. Overall survival (OS) and relapse-free survival (RFS) were the endpoints. Hazard ratios and 95% confidence intervals were assessed to evaluate the association between sarcopenia and survival of sarcoma patients.

Results

Eighteen studies with a total of 1699 patients met the inclusion criteria. Liposarcoma was the most

SUBMITTER: Albano D 

PROVIDER: S-EPMC12454457 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature