Preoperative Systemic Immune-Inflammatory Index Predicts Occult Nodal Disease in Clinically Node-Negative Intrahepatic Cholangiocarcinoma.

ABSTRACT:

Background

Accurate preoperative diagnosis of nodal status in intrahepatic cholangiocarcinoma (ICC) remains challenging. The objective of the current study was to determine if the systemic immune-inflammatory index (SII) was associated with occult nodal disease (OND) among cN0 patients undergoing resection for ICC.

Methods

Patients who underwent curative resection for ICC were identified from an international multi-institutional database. A multivariable logistic regression model was used to assess the relationship between SII and OND.

Results

Among 490 patients who underwent curative resection with lymph node dissection (LND) for cN0 ICC, 135 (27.6%) had OND. Among these individuals, high SII (≥738.4) was independently associated with OND (odds ratio [OR], 1.85, 95%

SUBMITTER: Kawashima J 

PROVIDER: S-EPMC12454466 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature