The Hidden Burden: Impact of Allostatic Load on Colorectal Cancer Surgery Outcomes.

ABSTRACT:

Background

Allostatic load (AL) is a composite measure of the physiological damage caused by socioenvironmental stressors. We sought to investigate the association between AL, social vulnerability index (SVI), and postoperative outcomes following colorectal cancer (CRC) surgery.

Patients and methods

Individuals who underwent surgery for CRC between 2022 and 2024 were identified using the Epic Cosmos database. AL is calculated on the basis of ten biomarkers from four physiological systems (cardiovascular, metabolic, renal, immune). Multivariable regression models were utilized to examine the association between AL and postoperative outcomes.

Results

Among 40,520 individuals, mean patient age was 67.7 years (SD ±13.9), roughly half of the patients were male (n = 20,573;

SUBMITTER: Khalil M 

PROVIDER: S-EPMC12454506 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature