Mechanobiology of gastric needle insertions: a combined experimental and numerical study.

ABSTRACT: The rising use of biologic drugs has increased the demand for alternative gastric administration methods. Inception of devices engineered to insert medication into the mucosal lining overcomes limitations of traditional administration methods. Mechanical forces from such microneedle insertions can affect tissue and cellular behavior, particularly mechanotransduction markers. This study investigates the effects of needle insertion in gastric tissue to inform the design of alternative drug delivery devices. Experimental and computational approaches were utilized, using tension and radial compression tests on porcine gastric tissue to inform a finite element analysis (FEA) model. This model was validated with atomic force microscopy (AFM)-based micro-indentation to examine stiffness variation

SUBMITTER: Friis SJ 

PROVIDER: S-EPMC12454536 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature