Tramadol (with or without acetaminophen) efficacy and harm: Systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the efficacy and safety of tramadol (with or without acetaminophen) in adult pain management compared with nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen alone.

Data sources

Studies were identified through a search of the entire Ovid MEDLINE database, the Ovid MEDLINE Epub Ahead of Print database, Embase, and Evidence-Based Medicine Reviews (Cochrane Central Register of Controlled Trials) from 1946 to August 19, 2022.

Study selection

Included studies comprised double-blind, randomized controlled trials (RCTs) of oral tramadol (with or without acetaminophen) compared with opioids, NSAIDs, or acetaminophen for treatment of acute or chronic pain that reported at least 1 of 11 outcomes: total adverse events (AEs), fatal ser

SUBMITTER: Otte JA 

PROVIDER: S-EPMC12454558 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature