Surgical Versus Nonsurgical Management of Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Pancreatic neuroendocrine tumors (PNETs) are a rare type of pancreatic cancer. Surgical resection is the primary curative treatment option, but whether this is the optimal treatment remains debatable. To address this question, we compared surgical versus nonsurgical management of PNETs.

Patients and methods

We searched the Medline (via PubMed), Scopus, Web of Science, and Embase databases through the end of 2023. Studies that compared surgical and nonsurgical interventions for PNETs across all grades, stages, and sizes and that reported survival outcomes were included. The primary endpoint was overall survival. The meta-analysis was performed using STATA software.

Results

Seventy-seven articles (including 62 654 patients) were included in the final analysis

SUBMITTER: Khajeh E 

PROVIDER: S-EPMC12454575 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature