Published Population Pharmacokinetic Models of Imatinib Perform Poorly on TDM Data from Pediatric Patients.

ABSTRACT:

Background

Population pharmacokinetic models can potentially provide suggestions for an initial dose and the magnitude of dose adjustment during therapeutic drug monitoring procedures of imatinib. Several population pharmacokinetic models for imatinib have been developed over the last two decades. However, their predictive performance is still unknown when extrapolated to different populations, especially children.

Objective

This study aimed to evaluate the predictive performance of these published models on an external real-world dataset containing data from both adults and children.

Methods

A real-world dataset was collected, containing observations from adult and pediatric patients with Philadelphia chromosome-positive/Philadelphia chromosome-like acute lymphoblast

SUBMITTER: Yang T 

PROVIDER: S-EPMC12454585 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature