Zebrafish exposed to a cocktail of pesticides during early development display long-lasting neurobehavioral alterations.

ABSTRACT: The widespread use of pesticides is increasing the presence of environmental contaminants with potential impacts on biodiversity, ecosystems, and human health. Although long-term pesticide effects have been previously studied, the long-term impact of an acute pesticide exposure during critical early developmental periods remains poorly understood. Here, we used zebrafish to examine whether acute exposure to a pesticide mixture at 0.5 μg/L (the maximum allowed in drinking water) during the first 5 days post-fertilisation (dpf) of development has lasting effects at 28 dpf. Zebrafish were assessed behaviourally, morphologically, and molecularly both immediately after exposure at 5 dpf and later at 28 dpf. Our results show alterations in stress-response that start to emerge right after the dev

SUBMITTER: Abellan-Alvaro M 

PROVIDER: S-EPMC12454604 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature