Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade.

ABSTRACT: The photoautotrophic lifestyle of cyanobacteria has to cope with the successive diurnal changes. We previously highlighted a unique function of the carbon control protein, SbtB, and its effector molecule c-di-AMP, for nighttime survival through the regulation of glycogen anabolism. However, the extent to which c-di-AMP and SbtB impact the cellular metabolism for day-night survivability remained elusive. To gain a better understanding, we compared the metabolomic and proteomic landscapes of ΔsbtB and the c-di-AMP-free (ΔdacA) mutants of Synechocystis sp. PCC 6803. While our results indicated that the cellular role of SbtB is restricted to carbon/glycogen metabolism, the diurnal lethality of ΔdacA seemed to be a sum of the dysregulation of multiple processes, incl

SUBMITTER: Haffner M 

PROVIDER: S-EPMC12454622 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature