Associations between sleep and the gut microbiome in adults with colorectal cancer and their caregivers.

ABSTRACT: Adults with cancer and their caregivers have elevated levels of sleep disturbances. In this cross-sectional exploratory study, we examined associations between subjective sleep indices and gut microbiome features among patients with colorectal cancer (CRC) and their sleep-partner caregivers. Forty participants (20 patient-caregiver dyads) completed sleep diaries, stool sampling, and dietary intake questionnaires individually. Patients and caregivers had comparable demographics, dietary and sleep indices. However, patients had significantly different beta diversity (p = .005) and alpha diversity (Inverse Simpson: p = .029) as well as 7 more and 6 less differentially abundant taxa compared with their caregivers. Furthermore, only patients categorized with high sleep efficiency (SE) (≥ 85%) a

SUBMITTER: Barb JJ 

PROVIDER: S-EPMC12454654 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature