Biophysical modeling of thalamic reticular nucleus subpopulations and their differential contribution to spindle dynamics.

ABSTRACT: Burst firing in thalamic reticular neurons is key to sleep rhythms and is linked to neurodevelopmental disorders. Several models of reticular neurons are currently available; however, a biophysically detailed model reproducing experimental burst firing heterogeneity is lacking. We addressed this by combining patch-clamp electrophysiology of fluorescently tagged Spp1+ and Ecel1+ neurons with a previously established statistical framework to differentiate cell types. We developed a population of biophysically detailed thalamic reticular models capturing diverse firing properties, particularly varied rebound bursting. These models incorporate key ion channels, such as T-type Ca²⁺ and small conductance potassium channels (SK), allowing systematic study of their impact on single-cell

SUBMITTER: Litvak P 

PROVIDER: S-EPMC12454877 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature