Epigenetic and Structural Brain Aging and Their Associations With Major Depressive Disorder.

ABSTRACT:

Background

A growing body of evidence suggests that major depressive disorder (MDD) may be associated with premature biological aging. However, most studies reported to date have examined brain-based (BrainAge) and DNA methylation (DNAm)-based measures (DNAmAge) of biological age (BioAge) in isolation.

Methods

We investigated 2 well-studied BioAge measures in lifetime and current MDD: BrainAge and DNAmAge (4 separate DNAmAge measures based on Horvath, Hannum, GrimAge, and PhenoAge clocks). We used cross-sectional cohort data from GS:STRADL (Generation Scotland: STratifying Resilience and Depression Longitudinally) (BrainAge n = 833; DNAmAge n = 587; age range 26-76 years) and used UK Biobank (UKB) data to test for replication of BrainAge associations with MDD (

SUBMITTER: Xu EY 

PROVIDER: S-EPMC12454886 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature