Hospital admissions due to adverse drug reactions and adverse drug events in older adults: a systematic review.

ABSTRACT:

Background

Adverse drug reactions (ADRs) and adverse drug events (ADEs) are consistently reported to cause up to 30% of hospital admissions in older adults, resulting in significant morbidity, mortality and an added health economic burden.This systematic review aimed to establish the frequency of ADRs and ADEs as a cause of hospitalisation in older adults.

Methods

Standard databases and citations were searched from 2015 to 2025. Studies specifically assessing ADR and ADE prevalence and risk factors in older adults were included. The review was registered in PROSPERO (CRD42024613426) and quality was assessed using the Joanna Briggs Institute criteria with bias determined via ROBINS-E.

Results

Nine studies underwent full evaluation. The reported prevalence of ADRs range

SUBMITTER: Cosgrave N 

PROVIDER: S-EPMC12454932 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature