Sex-Specific Differences in the Secretome of Oligodendrocyte Progenitor Cells Post Hyperoxic Stress.

ABSTRACT: Cerebral oxygenation differences in the neonatal period of human preterm infants, along with sex-specific differences in combating oxidative stress, can lead to disruption of normal oligodendrocyte maturation and function, which in turn can differentially affect neuronal development and activity in the male and female brains. Secretory proteins and extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication and stress response in the brain. Our analysis of the secretome from cell culture supernatants obtained after treating male and female derived primary mouse OPCs with hyperoxia (80% O₂) for a 24 h period showed prominent sex-specific protein signatures with only 6% intersection between sexes upon hyperoxia. A higher proportio

SUBMITTER: Sunny DE 

PROVIDER: S-EPMC12455015 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature