Incidence of laboratory-defined severe intravascular haemolysis across commercially available pulsed field ablation technologies for atrial fibrillation.

ABSTRACT:

Aims

Renal failure due to intravascular haemolysis (IH) has been reported after pulsed field ablation (PFA) of atrial fibrillation (AF). However, IH incidence using the accepted laboratory criteria is unknown.

Methods and results

In this prospective observational study (Sept 2024-May 2025), consecutive patients undergoing PFA for AF with pentaspline (PS), circular array (CA), or lattice tip (LT) catheters were included. Pre- and post-procedural labs and haemolysis biomarkers were collected. Significant IH was defined as post-procedure free plasma haemoglobin > 100 mg/dL per haematology criteria. Logistic regression (pooled and stratified) was used to identify IH predictors. Among 245 patients (66.9 ± 10.6 years; 68.2% male; 48.2% persistent), PFA was performed using the LT (

SUBMITTER: Mountantonakis SE 

PROVIDER: S-EPMC12455042 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature