Functional MRI reveals subcortical auditory push-pull interactions requiring intercollicular integrity.

ABSTRACT: The role of subcortical structures in binaural integration is of great interest for auditory processing. The inferior colliculus (IC) is the main auditory midbrain center where ascending and descending auditory projections converge, which was suggested to encode auditory information via a push-pull mechanism (a coordinated antagonistic neural mechanism for adaptive response control) between the two ICs. However, the origin of this push-pull mechanism in the brain and how it interacts with other upstream/downstream subcortical areas are still a matter of great debate. Here, we harness functional MRI (fMRI) in combination with IC lesions in the rat to dissect the push-pull interaction from a pathway-wide perspective. We find evidence for the push-pull mechanism in IC through opposing negativ

SUBMITTER: Severo F 

PROVIDER: S-EPMC12455056 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature