Frequency-dependence in multidimensional diffusion-relaxation correlation MRI of the brain: Overfitting or meaningful parameter?

ABSTRACT: Time- or frequency-dependent ("restricted") diffusion potentially provides useful information about cellular-scale structures in the brain but is challenging to interpret because of intravoxel tissue heterogeneity. Multidimensional diffusion-relaxation correlation MRI with tensor-valued diffusion encoding enables characterization of intravoxel heterogeneity in terms of nonparametric distributions of diffusion tensors and nuclear relaxation rates, and was recently augmented with explicit consideration of frequency-dependence to resolve the effects of restricted diffusion for distinct populations of tissue water. The simplest acquisition protocols for tensor-valued encoding unintentionally cover a frequency range of a factor 2-3, which can be extended in a more controlled way with oscillatin

SUBMITTER: Yon M 

PROVIDER: S-EPMC12455058 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature