Decreased Cerebral Blood Flow in Young Children With Prenatal Alcohol Exposure.

ABSTRACT:

Background

Alcohol exposure during pregnancy can hinder neurodevelopment, causing a range of behavioral and neurological deficits, including structural and functional brain alterations. Moreover, prenatal alcohol exposure (PAE) is associated with cerebral blood flow (CBF) abnormalities in preclinical models. However, it remains unclear to what extent CBF is affected by PAE in humans. In this study, we investigated CBF in young children with PAE.

Methods

A total of 171 scans collected from 99 children (35 children [51 scans] with PAE) between the ages of 3 to 8 years were examined. Children underwent a magnetic resonance imaging scan to acquire arterial spin labeling images to quantify CBF. CBF maps were segmented into 110 gray matter regions, and linear mixed models were use

SUBMITTER: Ghasoub M 

PROVIDER: S-EPMC12455085 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature